In 1891 David Hansemann observed asymmetric mitoses in all of the epithelial cancers he examined. This led him to the hypothesis that, “The cell of the malignant tumor is a cell with a certain abnormal chromatin content.”

Theodor Boveri formulated the first aneuploidy theory of cancer in 1914.

1st conference on aneuploidy and cancer 2004  Download my talk 12 Mb